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重要文件

T7816

Sigma-Aldrich

单克隆抗 β-微管蛋白 I 小鼠抗

clone SAP.4G5, ascites fluid

同義詞:

Anti-CDCBM6, Anti-CSCSC1, Anti-M40, Anti-OK/SW-cl.56, Anti-TUBB1, Anti-TUBB5

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About This Item

MDL號碼:
MFCD02095890
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

200

共軛

unconjugated

抗體表格

ascites fluid

抗體產品種類

primary antibodies

無性繁殖

SAP.4G5, monoclonal

分子量

antigen ~55 kDa

物種活性

Xenopus, chicken, human, hamster, canine, mouse, bovine, rat

技術

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:20,000 using cultured chicken fibroblasts

同型

IgG1

UniProt登錄號

P07437

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... TUBB(203068)
mouse ... Tubb4(22153)

相關類別

一般說明

微管蛋白是一种分子量为100 kDa 的蛋白，在所有细胞中以两种相似多肽α和ββ的异源二聚体形式存在并组装形成微管。微管的正确组装是细胞有丝分裂、减数分裂、某些形式的细胞器运动、细胞内转运、鞭毛运动和细胞骨架功能等多种细胞功能的必要基础。抗β-微管蛋白 I 单克隆抗体可用于 ELISA 定位β微管蛋白亚型 I，并可用于免疫印迹定位培养的人类和动物细胞。小鼠抗β-微管蛋白 I 抗体与人、大鼠、狗、牛、仓鼠、小鼠、鸡和爪蟾的β微管蛋白 C 末端序列中的表位发生特异性反应

特異性

识别一个位于 β-微管蛋白同种型 I 羧基端序列的表位。未观察到与其他微管蛋白同种型的反应。

免疫原

对应于 β-微管蛋白同种型 I 羧基端序列的合成肽，与 BSA 偶联。

應用

抗β-微管蛋白 I 单克隆抗体（稀释度1：4,000) 可用作免疫沉淀和免疫印迹中的一抗。它还可用于蛋白质印迹分析和逆转录病毒感染。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

nwg

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
068M4850V
22180407
058M4754V
087M4877V
025M4776V

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A A Atwood et al.
Oncogene, 29(45), 6004-6015 (2010-09-08)
Overexpression of Ras(V12) in MCF10A cells, an immortalized mammary epithelial cell line, leads to transformation of these cells. We demonstrate that this is accompanied by degradation of C/EBPbeta1. C/EBPbeta is a transcription factor in which three protein isoforms exist because
Geza Gemes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(10), 3536-3549 (2011-03-11)
Painful nerve injury disrupts levels of cytoplasmic and stored Ca(2+) in sensory neurons. Since influx of Ca(2+) may occur through store-operated Ca(2+) entry (SOCE) as well as voltage- and ligand-activated pathways, we sought confirmation of SOCE in sensory neurons from
Yosef Buganim et al.
Cancer research, 66(22), 10750-10759 (2006-11-17)
Mutations in p53 are ubiquitous in human tumors. Some p53 mutations not only result in loss of wild-type (WT) activity but also grant additional functions, termed "gain of function." In this study, we explore how the status of p53 affects
Nathan D Camp et al.
The Journal of biological chemistry, 287(9), 6539-6550 (2012-01-05)
WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms tumor. Among its known functions, WTX interacts with the β-transducin repeat containing family of ubiquitin ligase adaptors and promotes the ubiquitination
Ning Zhao et al.
Circulation research, 116(1), 23-34 (2014-10-18)
MicroRNA miR145 has been implicated in vascular smooth muscle cell differentiation, but its mechanisms of action and downstream targets have not been fully defined. Here, we sought to explore and define the mechanisms of miR145 function in smooth muscle cells.
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文章

Antibodies to Tubulins, including Centrosome-Associated ε-Tubulin

Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.

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