推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat
技術
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProt登錄號
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... KCNK2(3776)
rat ... Kcnk2(170899)
一般說明
Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family.
特異性
The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18).
免疫原
synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28).
應用
Anti-TREK-1 antibody produced in rabbit has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化／生理作用
Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia.
外觀
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Analysis of gene expression profiles in the programmed cell death rat retinal ganglion cells (RGC-5).
Abdelnaby K, et al.
Cancer Therapy, 6(2) (2008)
Naaz Andharia et al.
Channels (Austin, Tex.), 11(3), 224-235 (2017-01-14)
The TREK-1 channel, the TWIK-1-related potassium (K
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats
Chunlin C, et al.
Acta Pharmaceutica Sinica. B, 5(1), 55-61 (2015)
Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction
Junlong Z,et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 1064-1064 (2018)
Chunlin Chen et al.
Acta pharmaceutica Sinica. B, 5(1), 55-61 (2015-11-19)
The purpose of this study is to investigate the expression of major potassium channel subtypes in the brain of chronical mild stress (CMS) rats and reveal the effects of fluoxetine on the expression of these channels. Rats were exposed to
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