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Key Documents

T4510

Sigma-Aldrich

胸苷5′-单磷酸对硝基苯酯 钠盐

chromogenic, ≥98% (HPLC), powder

同義詞:

p-Nph-5V-TMP, -硝基苯基-5V-胸苷一磷酸

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About This Item

經驗公式(希爾表示法):
C16H18N3O10PNa
CAS號碼:
分子量::
466.29
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

product name

胸苷5′-单磷酸对硝基苯酯 钠盐, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL

儲存溫度

−20°C

SMILES 字串

CC(C(N1)=O)=CN([C@H]2C[C@H](O)[C@@H](COP(O)(OC(C=C3)=CC=C3[N+]([O-])=O)=O)O2)C1=O.[Na]

InChI

1S/C16H18N3O10P.Na.H/c1-9-7-18(16(22)17-15(9)21)14-6-12(20)13(28-14)8-27-30(25,26)29-11-4-2-10(3-5-11)19(23)24;;/h2-5,7,12-14,20H,6,8H2,1H3,(H,25,26)(H,17,21,22);;

InChI 密鑰

PHNRUCBIIRECII-UHFFFAOYSA-N

相關類別

應用

胸苷5′-单磷酸硝基苯酯钠盐已被用作评估磷酸二酯酶活性的底物。它也被用作autotaxin抑制检测中的核苷酸类似物。

生化/生理作用

胸苷5′-单磷酸硝基苯酯钠盐是5′-核苷酸磷酸二酯酶活性的一种人工底物标记。它也可用作胞外核苷酸焦磷酸酶/磷酸二酯酶(NPP)酶家族成员autotaxin(ATX,NPP2)的底物。

基底

毒磷酸二酯酶的一种灵敏的生色底物。它不会被牛脾脏磷酸二酯酶水解。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Soluble NTPDase: an additional system of nucleotide hydrolysis in rat blood serum.
Oses JP, et al.
Life Sciences, 74(26), 3275-3284 (2004)
Characterization of non-lipid autotaxin inhibitors.
Hoeglund AB, et al.
Bioorganic & Medicinal Chemistry, 18(2), 769-776 (2010)
Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes.
Vuaden FC, et al.
European Journal of Pharmacology, 651(1-3), 212-217 (2011)
Molhm Nassir et al.
Organic & biomolecular chemistry, 17(46), 9913-9923 (2019-11-14)
Nucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) inhibitors have been suggested as a potential treatment for calcium pyrophosphate dihydrate (CPPD) deposition disease. Here, we targeted the development of improved NPP1 inhibitors based on acyclic mimics of Pα,α-phosphorodithioate-substituted adenine nucleotides, 7-10. The latter were obtained
Ortal Danino et al.
Rheumatology (Oxford, England), 57(8), 1472-1480 (2018-04-25)
Calcium pyrophosphate deposition (CPPD) is associated with osteoarthritis and is the cause of a common inflammatory articular disease. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (eNPP1) is the major ecto-pyrophosphatase in chondrocytes and cartilage-derived matrix vesicles (MVs). Thus, eNPP1 is a principle contributor to

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