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Merck
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重要文件

T4321

SAFC

L-酪氨酸

製藥生產

同義詞:

(S)-2-氨基-3-(4-羟苯基)丙酸, 3-(4-羟苯基)-L-丙氨酸

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About This Item

線性公式:
4-(HO)C6H4CH2CH(NH2)CO2H
CAS號碼:
分子量::
181.19
Beilstein:
392441
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406

生物源

non-animal source

品質等級

化驗

≥99%

形狀

crystalline powder

技術

cell culture | mammalian: suitable

雜質

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

>300 °C (dec.) (lit.)

溶解度

1 M HCl: 25 mg/mL

應用

pharmaceutical (small molecule)

異物活動

cytotoxicity, tested

SMILES 字串

N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI 密鑰

OUYCCCASQSFEME-QMMMGPOBSA-N

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我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。

M-Clarity Program

我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

應用

L-酪氨酸是一种具有极性侧链基团的非必需氨基酸。 它可用作细胞培养基组分,用于治疗性重组蛋白和单克隆抗体的商业生物制造过程。

其他說明

多巴胺和其他儿茶酚胺的氨基酸前体

法律資訊

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Keisuke Saito et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(19), 7690-7695 (2013-04-20)
Using quantum mechanics/molecular mechanics calculations and the 1.9-Å crystal structure of Photosystem II [Umena Y, Kawakami K, Shen J-R, Kamiya N (2011) Nature 473(7345):55-60], we investigated the H-bonding environment of the redox-active tyrosine D (TyrD) and obtained insights that help
Hideki Hara et al.
Nature immunology, 14(12), 1247-1255 (2013-11-05)
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases Syk and Jnk were required for the activation of caspase-1 via the ASC-dependent inflammasomes NLRP3 and AIM2.
Verena Rahm et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(4), 546-550 (2014-02-26)
Low-grade gliomas (LGGs) may harbor malignant foci, which are characterized by increased tumor cellularity and angiogenesis. We used diffusion-weighted MR imaging (apparent diffusion coefficient [ADC]) and PET with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of diffusion
Alena Volgusheva et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7223-7228 (2013-04-17)
Photobiological H2 production is an attractive option for renewable solar fuels. Sulfur-deprived cells of Chlamydomonas reinhardtii have been shown to produce hydrogen with the highest efficiency among photobiological systems. We have investigated the photosynthetic reactions during sulfur deprivation and H2
Bart Pennings et al.
The American journal of clinical nutrition, 98(1), 121-128 (2013-05-03)
Older individuals generally experience a reduced food-chewing efficiency. As a consequence, food texture may represent an important factor that modulates dietary protein digestion and absorption kinetics and the subsequent postprandial protein balance. We assessed the effect of meat texture on

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