推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
顏色
white
溶解度
H2O: >20 mg/mL
儲存溫度
room temp
SMILES 字串
Cl.CC(CN1CCCCC1)C(=O)c2ccc(C)cc2
InChI
1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
InChI 密鑰
ZBUVYROEHQQAKL-UHFFFAOYSA-N
尋找類似的產品？ 前往 產品比較指南
生化／生理作用
Tolperisone is an ion channel blocker and centrally acting muscle relaxant.
Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.
Tolperisone regulates ionic currents in myelinates axons and subsequently decreases excitability and mediates its antispastic functions3.
準備報告
Tolperisone hydrochloride dissolves in water at a concentration that is greater than 20 mg/ml.
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
客戶也查看了
A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke
Stamenova P, et al.
European Journal of Neurology, 12(6), 453-461 (2005)
D Hinck et al.
General physiology and biophysics, 20(4), 413-429 (2002-05-07)
The actions of tolperisone on single intact Ranvier nodes of the toad Xenopus were investigated by means of the Hodgkin-Huxley formalism. Adding tolperisone to the bathing medium (100 micromol/l) caused the following fully reversible effects: 1. The sodium permeability P'Na
Pál Kocsis et al.
The Journal of pharmacology and experimental therapeutics, 315(3), 1237-1246 (2005-08-30)
The spinal reflex depressant mechanism of tolperisone and some of its structural analogs with central muscle relaxant action was investigated. Tolperisone (50-400 microM), eperisone, lanperisone, inaperisone, and silperisone (25-200 microM) dose dependently depressed the ventral root potential of isolated hemisected
Doris Hofer et al.
European journal of pharmacology, 538(1-3), 5-14 (2006-05-03)
The specific, acute interaction of tolperisone, an agent used as a muscle relaxant and for the treatment of chronic pain conditions, with the Na(v1.2), Na(v1.3), Na(v1.4), Na(v1.5), Na(v1.6), Na(v1.7), and Na(v1.8) isoforms of voltage dependent sodium channels was investigated and
HPLC determination of tolperisone in human plasma
Bae JW, et al.
Archives of Pharmacal Research, 29(4), 339-342 (2006)
文章
Sigma-Aldrich offers many products related to sodium channels for your research needs.
Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.
Chromatograms
application for HPLC我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務