推薦產品
品質等級
化驗
≥97% (HPLC)
形狀
solid
顏色
white to off-white
溶解度
H2O: 16 mg/mL
DMSO: insoluble
SMILES 字串
[H]O[H].CP([O-])(=O)C1=CC[NH2+]CC1
InChI
1S/C6H12NO2P.H2O/c1-10(8,9)6-2-4-7-5-3-6;/h2,7H,3-5H2,1H3,(H,8,9);1H2
InChI 密鑰
GXVWAQPRAQORGS-UHFFFAOYSA-N
應用
(1,2,5,6-四氢吡啶-4-基)甲基次磷酸(TPMPA)水合物已用作视网膜神经节细胞的γ-氨基丁酸C(GABAc)抑制剂。
TPMA已作为GABAC受体拮抗剂，研究侏儒神经节细胞中的内层视网膜抑制作用。TPMPA还用于研究GABAC受体拮抗剂抑制神经节细胞定向选择性的作用。
生化／生理作用
TPMPA融合异四氢烟酸和3-APMPA特性，既保留GABAC受体亲和性，又不与GABAA或GABAB受体作用。电活动分析表明，TPMPA是非洲爪蟾卵母细胞表达克隆人mu 1 GABAC受体的竞争性拮抗剂（Kb约2μM）。TPMPA是弱>100倍的卵母细胞表达的大鼠脑GABAA受体抑制剂（Kb约320 μM），对大鼠海马体切片中的GABAB受体仅有较弱的激动剂活性（EC50约500 μM）。TPMPA 可用于研究视网膜外层和神经系统中其他受体表达区域中的GABAC受体功能。
特點和優勢
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
準備報告
(1,2,5,6-四氢吡啶-4-基)甲基次磷酸(TPMPA)水合物可溶于水(16 mg/ml)，但不溶于DMSO。
法律資訊
根据加利福尼亚大学授予的独家许可在美国销售。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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