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T1157

Sigma-Aldrich

(+)-α-生育酚乙酸酯

BioReagent, suitable for insect cell culture, ~1360 IU/g

同義詞:

维生素 E 醋酸酯

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About This Item

經驗公式（希爾表示法）:
C31H52O3
CAS號碼:
58-95-7
分子量：:
472.74
EC號碼:
200-405-4
MDL號碼:
MFCD00072052
分類程式碼代碼:
12352205
eCl@ss:
34058007
PubChem物質ID:
24899940
NACRES:
NA.75

生物源

plant

描述

Synthesized from natural α-tocopherol

產品線

BioReagent

形狀

liquid (or semi-solid)

比活性

~1360 IU/g

分子量

Mw 472.74 g/mol

純化經由

crystallization

技術

cell culture | insect: suitable

顏色

white to yellow

溶解度

chloroform: soluble 50 mg/mL, clear, colorless to yellow

儲存溫度

room temp

SMILES 字串

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI 密鑰

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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相關類別

一般說明

α-生育酚乙酸酯是天然存在 α-生育酚的半合成醋酸酯。

應用

在昆虫细胞培养中用作抗氧化剂。
（+）-α生育酚乙酸酯用于：
  • 作为补充剂，用于培养人胚胎肾细胞（HEK 293），评估其对细胞生长的影响
  • 作为组成成分，用于Dulbecco′s改良Eagle培养基/营养混合物F-12（DMEM / F12），培养永生化软骨细胞系
  • 作为无血清培养基成分，用于培养人类结肠组织器官
  • 试验其对牛关节软骨细胞的抗氧化作用

生化／生理作用

α-生育酚乙酸酯或维生素E-乙酸酯具有抗氧化性能，减少脂质过氧化。不过，维生素E乙酸酯热分解会导致产生烯烃和苯之类致癌物。

注意

因为熔点约为 25℃，所以这种制剂通常是油。不发生空气氧化。

危險聲明

H413

防範說明

P273 - P501

危險分類

Aquatic Chronic 4

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

個人防護裝備

Eyeshields, Gloves

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCL1318
SLCH1778
SLBZ9611
SLBZ4654
SLBX4005

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Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 46(2), 114-122 (2009-11-17)
Normal and neoplastic human colon tissue obtained at surgery was used to establish conditions for organ culture. Optimal conditions included an atmosphere of 5% CO2 and 95% O2; tissue partially submerged with mucosa at the gas interface; and serum-free medium
Optimization of HEK 293 cell growth by addition of non-animal derived components using design of experiments.
Laura Cervera et al.
BMC proceedings, 5 Suppl 8, P126-P126 (2012-03-01)
Michael K Dame et al.
In vitro cellular & developmental biology. Animal, 47(1), 32-38 (2010-11-26)
We have recently shown that a multi-mineral extract from the marine red algae, Lithothamnion calcareum, suppresses colon polyp formation and inflammation in mice. In the present study, we used intact human colon tissue in organ culture to compare responses initiated
Dan Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(12), 6349-6355 (2020-03-12)
A combined analytical, theoretical, and experimental study has shown that the vaping of vitamin E acetate has the potential to produce exceptionally toxic ketene gas, which may be a contributing factor to the upsurge in pulmonary injuries associated with using
Brandon Mapes et al.
Physiological genomics, 46(8), 302-308 (2014-02-20)
1α,25-Dihydroxyvitamin D3 [1α,25(OH)2D3] is a steroid hormone derived from circulating 25(OH) vitamin D [25(OH)D] with chemopreventive effects in colorectal cancer. 1α,25(OH)2D3 acts through transcriptional mechanisms; however, our understanding of vitamin D transcriptional responses in the colon is derived from studies
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