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Key Documents

T0451

Sigma-Aldrich

Tau-410 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE), lyophilized powder

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About This Item

MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥85% (SDS-PAGE)

形狀

lyophilized powder

分子量

42.6 kDa

UniProt登錄號

應用

cell analysis

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... MAPT(4137)

生化/生理作用

Isoform of Tau, variant 2N3R, having 3 microtubule binding repeats (R) and 2 amino terminal inserts (N).

重構

Lyophilized from MES, pH 6.8 containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl and 0.5 mM EGTA.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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A Himmler et al.
Molecular and cellular biology, 9(4), 1381-1388 (1989-04-01)
Tau proteins consist of a family of proteins, heterogeneous in size, which associate with microtubules in vivo and are induced during neurite outgrowth. In humans, tau is one of the major components of the pathognomonic neurofibrillary tangles in Alzheimer's disease
Jesus Avila et al.
Physiological reviews, 84(2), 361-384 (2004-03-27)
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with

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