SRP8052

CD279 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 同義詞: Hepatitis A virus cellular receptor 2, PD-1, Programmed cell death protein 1
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: monomer 46 kDa by calculation
• 包裝: pkg of 100 μg
• 雜質: <0.06 EU/μg endotoxin, tested
• UniProt登錄號: Q15116
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... PDCD1(5133)

描述

一般說明

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-γ. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

外觀

Lyophilized from 0.2 μm-filtered solution in PBS.

重構

Reconstitute at 100 μg/mL in sterile PBS.

其他說明

The extracellular domain of human CD279 [PD-1] (aa 25-167) is fused to the N-terminus of the Fc region of human IgG1.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable