SRP8050

Profilin from Toxoplasma gondii

recombinant, expressed in E. coli, >95% (SDS-PAGE)

• 同義詞: Inflammatory profilin, T Cell Membrane Protein 1
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: Toxoplasma gondii
• 重組細胞: expressed in E. coli
• 化驗: >95% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: ~20 kDa by SDS-PAGE
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 雜質: <0.01 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: Q58NA1
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: Toxoplasma gondii ... PRF(7900190)

描述

生化／生理作用

Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.

外觀

Lyophilized from PBS.

重構

Reconstitute with 100 μL deionized water.

其他說明

Recombinant profilin (Toxoplasma gondii) (aa 1-163).

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable