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產品名稱
Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
生物源
mouse
重組細胞
expressed in E. coli
籤條
His tagged
化驗
>90% (SDS-PAGE)
形狀
liquid
分子量
~45 kDa by SDS-PAGE
包裝
pkg of 50 μg
儲存條件
avoid repeated freeze/thaw cycles
濃度
≥0.2 mg/mL
雜質
<1 EU/μg endotoxin, tested
顏色
clear
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Clu(12759)
一般說明
Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.
生化／生理作用
Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.
外觀
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
其他說明
Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
Jung GS
PLoS ONE, 9, e105635-e105635 (2014)
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
Afanasyeva MA, et al.
PLoS ONE, 9, e98349-e98349 (2014)
Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.
Byun K, et al.
The Embo Journal, 15, 801-801 (2014)
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
Hong GH, et al.
Journal of Immunology, 196, 2021-2021 (2001)
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.
Caccamo AE, et al.
Cell Death and Differentiation, 12, 101-101 (2005)
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