SRP6576

CREB Binding Protein (1081-1197) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 同義詞: CBP
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥95% (SDS-PAGE)
• 形狀: liquid
• 分子量: 40.8 kDa (1081-1197 aa + NT GST Tag)
• 包裝: pkg of 20 and 100 μg
• UniProt登錄號: Q92793
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... CREB1(1385)

描述

一般說明

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.

外觀

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317 - H319 - H412
• 防範說明: P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313
• 危險分類: Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable