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Key Documents

SRP5030

Sigma-Aldrich

FGFR2 (285-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution

同義詞:

BFR-1, CD332, CEK3, ECT1, JWS, K-SAM, TK14, TK25

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About This Item

分類程式碼代碼:
51111800
NACRES:
NA.32

重組細胞

expressed in baculovirus infected Sf9 cells

產品線

PRECISIO® Kinase

化驗

≥80% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

100-136 nmol/min·mg

分子量

~72 kDa

NCBI登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... FGFR2(2263)

一般說明

FGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. FGFR2 is required for early postimplantation development between implantation and the formation of the egg cylinder. FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass.

外觀

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

準備報告

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Shih-hsin Kan et al.
American journal of human genetics, 70(2), 472-486 (2002-01-10)
It has been known for several years that heterozygous mutations of three members of the fibroblast growth-factor-receptor family of signal-transduction molecules-namely, FGFR1, FGFR2, and FGFR3-contribute significantly to disorders of bone patterning and growth. FGFR3 mutations, which predominantly cause short-limbed bone
E Arman et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(9), 5082-5087 (1998-06-06)
We disrupted the fibroblast growth factor (FGF) receptor 2 (FGFR2) gene by introducing a neo cassette into the IIIc ligand binding exon and by deleting a genomic DNA fragment encoding its transmembrane domain and part of its kinase I domain.

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