SRP5004
AMPK (α2/β2/γ2), active, His tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
同義詞:
AAKG, AAKG2, AMPK, AMPK2, CMH6, H91620p, MGC61468, PRKAA, PRKAA2, PRKAB2, PRKAG2, WPWS
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About This Item
分類程式碼代碼:
12352202
NACRES:
NA.77
重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
255-345 nmol/min·mg
分子量
~36 kDa (B2)
~65 kDa (G2)
~69 kDa (A2)
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PRKAA2(5563) , PRKAB2(5565) , PRKAG2(51422)
一般說明
AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis. AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) and via signaling pathways in response to adiponectin, leptin and CAMKKβ.
外觀
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
準備報告
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Barbara B Kahn et al.
Cell metabolism, 1(1), 15-25 (2005-08-02)
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the
D Grahame Hardie
Journal of cell science, 117(Pt 23), 5479-5487 (2004-10-29)
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that inhibits ATP production or increases ATP consumption, this is amplified by adenylate kinase into a much
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