推薦產品
生物源
human
重組細胞
expressed in (BTI-Tn-5B1-4) High-5 Insect Cells
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
31.5 kDa
包裝
pkg of 20 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IGFBP2(3485)
一般說明
IGFBPs (insulin-like growth factor-binding proteins) are mainly required to regulate IGFs (insulin-like growth factors) activities. IGFBP-2 belongs to the IGFBP family of proteins. The protein has a IGF-binding site and a thyroglobulin type-1 domain. It interacts with IGF1 and IGF2. IGFBP-2 is widely expressed in tissues. This gene is mapped to human chromosome 2q35.
Recombinant human IGF-BP2 is a 31.5kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Recombinant human IGF-BP2 is a 31.5kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
應用
IGF-Binding Protein 2 human has been used to study the vaccine-stimulated augmented immunity in the presence of IGFBP-2 in patients with metastatic breast cancer.
生化／生理作用
IGFBP-2 (insulin-like growth factor-binding protein 2) interacts with integrins and extracellular matrix via arginine-glycine-aspartic acid (RGD) and heparin-binding motifs. It participates in cell detachment, migration and invasion. IGFBP-2 is also associated with various malignancies, including ovarian cancer, breast cancer, colon cancer, lung cancer, prostate cancer, glioma and leukemia. It is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients. IGFBP-2 is upregulated in idiopathic pulmonary fibrosis.
序列
EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ
外觀
Lyophilized from 1x PBS, pH 7.2.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer.
Disis ML, et al.
Journal of Clinical Oncology, 27, 4685-4685 (2009)
IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma.
Myers AL, et al.
Oncotarget, 6, 25897-25897 (2015)
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis.
Guiot J, et al.
BMC Pulmonary Medicine, 16, 86-86 (2016)
Cheryl A Conover et al.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 13(6), 328-335 (2003-11-20)
Insulin-like growth factor binding protein-2 (IGFBP-2) in its native form had little affinity for extracellular matrix (ECM) derived from human or rat osteoblastic cells. However, in the presence of IGFs, IGFBP-2 binding to ECM was markedly enhanced, with IGF-II being
Insulin-like growth factor binding protein-2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis.
Ding H, et al.
Clinical and Experimental Immunology, 184, 11-11 (2016)
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