生物源
human
重組細胞
expressed in E. coli
化驗
≥70% (SDS-PAGE)
形狀
frozen liquid
分子量
~55.3 kDa
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
濃度
100 μg/mL
顏色
clear
colorless
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... NR1I3(9970)
一般說明
The gene encoding this protein is localized on human chromosome 1q23.3.
生化／生理作用
It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.
The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.
外觀
Clear and colorless frozen liquid solution
準備報告
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Expression of CAR in SW480 and HepG2 cells during G1 is associated with cell proliferation.
Osabe M
Biochemical and Biophysical Research Communications, 369(4), 1027-1033 (2008)
High resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?
Cheung TP
Gene, 573(2), 198-204 (2015)
Molecular Genetic Studies of Gene Identification for Osteoporosis: The 2009 Update
Xiang-Hong Xu
Endocrine Reviews, 31(4), 447-505 (2010)
The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor ? and Contributes to the Development of Experimental Dermal Fibrosis
Jerome Avouac
Arthritis & Rheumatology (Hoboken, N.J.) (2014)
P Wei et al.
The pharmacogenomics journal, 2(2), 117-126 (2002-06-07)
The products of the cytochrome P450 (CYP) genes play an important role in the detoxification of xenobiotics and environmental contaminants, and many foreign chemicals or xenobiotics can induce their expression. We have previously shown that the nuclear hormone receptor CAR
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