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Key Documents

SRP2059

Sigma-Aldrich

RARα-ligand binding domain (154-462) human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

同義詞:

NR1B1, RAR

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.26

生物源

human

重組細胞

expressed in E. coli

化驗

≥70% (SDS-PAGE)

形狀

frozen liquid

分子量

~36.4 kDa

包裝

pkg of 10 μg

儲存條件

avoid repeated freeze/thaw cycles

濃度

500 μg/mL

顏色

clear colorless

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... RARA(5914)

生化/生理作用

Several members of nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor α (RARα) in acute promyelocytic leukemia. Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consists of three isotypes ( α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The retinoic acid receptor alpha gene is the target of chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). RAR alpha is a negative regulator of promyelocyte differentiation when not complexed with RA, and stimulates this differentiation when bound to RA.

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Stephen M Hart
Biological research, 35(2), 295-303 (2002-11-06)
Nuclear receptors comprise a family of transcription factors that regulate gene expression in a ligand dependent manner. They can activate or repress target genes by binding directly to DNA response elements as homo- or hetero-dimers or by binding to other
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?
P Kastner et al.
Cell, 83(6), 859-869 (1995-12-15)
M Leid et al.
Trends in biochemical sciences, 17(10), 427-433 (1992-10-01)
Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric

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