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Merck
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重要文件

SRP0437

Sigma-Aldrich

PDE7B active rat

recombinant, expressed in baculovirus infected Sf9 cells, ≥30% (SDS-PAGE)

同義詞:

phosphodiesterase 7B

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

rat

重組細胞

expressed in baculovirus infected Sf9 cells

化驗

≥30% (SDS-PAGE)

形狀

aqueous solution

分子量

65 kDa

包裝

pkg of 10 μg

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

一般說明

Rat PDE7B (GenBank Accession No. NM_080894) amino acids 108-446 (end) with N-terminal GST-tag, MW=65 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.

應用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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E Reyes-Irisarri et al.
Neuroscience, 132(4), 1173-1185 (2005-04-29)
cAMP plays an important role as second messenger molecule controlling multiple cellular processes in the brain. cAMP levels depend critically on the phosphodiesterases (PDE) activity, enzymes responsible for the clearance of intracellular cAMP. We have examined the regional distribution and
C Gardner et al.
Biochemical and biophysical research communications, 272(1), 186-192 (2000-06-29)
We have identified and characterised a novel member of the PDE7 family of cyclic nucleotide phosphodiesterases (PDE), which we have designated PDE7B. Mouse and human full-length cDNAs were isolated encoding a protein of 446 and 450 amino acids, respectively. The
Lingzhi Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(49), 19532-19537 (2008-11-27)
Cyclic nucleotide phosphodiesterase (PDE) isoforms can influence disease pathogenesis and be novel therapeutic targets. Because lower cAMP levels may contribute to the decreased apoptosis that occurs in chronic lymphocytic leukemia (CLL), we assessed the expression levels of PDE isoforms in

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