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重要文件

SRP0399

Sigma-Aldrich

Histone H3 peptide (Mono-methylated K9), biotin

≥95% (HPLC)

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

aqueous solution

包裝

pkg of 500 μL

濃度

40 μM

運輸包裝

dry ice

儲存溫度

−70°C

一般說明

Histone H3 peptide mono-methylated at Lysine 9, biotinylated, substrate for histone demethylases belonging to the Jumanji domain-containing (JMJ) family .

應用

Suitable as a substrate for histone demethylases belonging to the Jumonji (JMJ) family. It can be used to study enzyme kinetics, and to screen small molecular inhibitors of these demethylases for drug discovery and HTS applications.

其他說明

500 μL at 40 μM, or 20 nmol Sold as 500 μL

儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Shiv I S Grewal et al.
Current opinion in cell biology, 16(3), 230-238 (2004-05-18)
Heterochromatin mediates various nuclear processes including centromere function, gene silencing and nuclear organization. Although it was discovered nearly 75 years ago, the pathways involved in heterochromatin establishment, assembly and epigenetic maintenance have been elusive. Recent reports have demonstrated that distinct
Judd C Rice et al.
Molecular cell, 12(6), 1591-1598 (2003-12-24)
The functional significance of mono-, di-, and trimethylation of lysine residues within histone proteins remains unclear. Antibodies developed to selectively recognize each of these methylated states at histone H3 lysine 9 (H3 Lys9) demonstrated that mono- and dimethylation localized specifically

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