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Merck
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重要文件

SRP0387

Sigma-Aldrich

EZH2 /EED/SUZ12/RbAp48/AEBP2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥56% (SDS-PAGE)

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in baculovirus infected Sf9 cells

化驗

≥56% (SDS-PAGE)

形狀

aqueous solution

分子量

87 kDa (EZH2)

包裝

pkg of 20 μg

運輸包裝

dry ice

儲存溫度

−70°C

一般說明

Mutant version of EZH2 5- member complex with a Tyr-to-Asn mutation on amino acids 646 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), amino acids 2-end (Y646N*) with N-terminal His-tag, MW= 86 kDa, human EED (GenBank Accession No. NM_003797) (amino acids 2-end) with N-terminal Flag-tag, MW= 51 kDa, human SUZ12 (GenBank Accession No. NM_015355) (amino acids 2-end) with N-terminal His-tag, MW = 87 kDa, Human AEBP2 (GenBank Accession No. NM_153207) (amino acids 2-end) with N-terminal His-tag, MW= 53 kDa, and human RbAp48 (GenBank Accession No. NM_005610) (a-a 2- end) with N-terminal His-tag, MW = 48 kDa, co-expressed in Baculovirus expression system. *This mutation is often cited as Y641N in variant 3 GenBank Accession No. NM_001203247).

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Rakotobe, D. et al.
Journal of Virology, 5, 32-32 (2008)
Sooryanarayana Varambally et al.
Science (New York, N.Y.), 322(5908), 1695-1699 (2008-11-15)
Enhancer of zeste homolog 2 (EZH2) is a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells. EZH2 is overexpressed in aggressive solid tumors by mechanisms that remain

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