SML3941

DUB-IN-1

≥98% (HPLC)

• 同義詞: 9-Benzyloxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 9-Phenylmethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, DUB Inhibitor 1, DUBs Inhibitor 1, DUBs-IN-1, Deubiquitinase Inhibitor 1
• 經驗公式（希爾表示法）: C₂₀H₁₁N₅O
• CAS號碼: 924296-18-4
• 分子量：: 337.33
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C

描述

生化／生理作用

Potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor.

DUB-IN-1 is a potent and selective ubiquitin specific peptidase USP8 deubiquitinase (DUB) inhibitor (IC50 = 850 nM/USP8, >100 µM/USP7). DUB-IN-1 inhibits the proliferation (200-800 nM for 24 or 48h; LN229, U87MG, and T98G cells), invasion (500-800 nM for 48 or 96h; LN229 and T98G cells), and stemness (500-800 nM for 7 or 14 days; LN229 and T98G cells) in GBM cultures.