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Merck
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重要文件

SML3708

Sigma-Aldrich

L-Meta-tyrosine

≥98% (HPLC)

同義詞:

(S)-2-Amino-3-(3-hydroxyphenyl)propanoic acid, 3-Hydroxy-L-phenylalanine, L-3-Hydroxyphenylalanine, L-m-Tyrosine, m-Tyr, meta-Tyrosine

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About This Item

經驗公式(希爾表示法):
C9H11NO3
CAS號碼:
分子量::
181.19
MDL號碼:
分類程式碼代碼:
12352209
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

2 mg/mL, clear (0.1N HCl)

儲存溫度

-10 to -25°C

SMILES 字串

[N+H3][C@@H](Cc1cc(ccc1)O)C(=O)[O-]

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-2-1-3-7(11)4-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

生化/生理作用

L-Meta-tyrosine is metabolite of L-Phenylalanine generated within the living organism by hydroxyl free radical. It is a marker of oxidative stress. Circulating L-Meta-tyrosine cold be incorporated into protein through the binding to the tRNAPhe. In plants L-Meta-tyrosine (m-Tyr) is also synthesized enzymatically and has been shown to act as a natural herbicide. It inhibits the growth of plants. L-Meta-tyrosine is a potent and selective competitive inhibitor of Enterobacteriaceae (Citrobacter, Proteus, Erwinia) tyrosine phenol-lyase that exhibits a renoprotective effect in diabetic mice. L-Meta-tyrosine decreases plasma phenyl sulfate and indoxyl sulfate levels and reduces albuminuria in diabetic mice models. Also, L-Meta-tyrosine inhibits bacterial tryptophan indole-lyase. It does not alter composition of microbiota in renal failure mice model.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Marcin Tyminski et al.
Plants (Basel, Switzerland), 10(12) (2021-12-29)
L-Tyrosine (Tyr) is one of the twenty proteinogenic amino acids and also acts as a precursor for secondary metabolites. Tyr is prone to modifications, especially under conditions of cellular redox imbalance. The oxidation of Tyr precursor phenylalanine leads to the
Judit Mohás-Cseh et al.
Biomedicines, 10(5) (2022-05-29)
A link between oxidative stress and insulin resistance has been suggested. Hydroxyl free radicals are known to be able to convert phenylalanine (Phe) into the non-physiological tyrosine isoforms ortho- and meta-tyrosine (o-Tyr, m-Tyr). The aim of our study was to

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