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Merck
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重要文件

SML3612

Sigma-Aldrich

Ganoderic acid D

≥95% (HPLC)

同義詞:

(7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid, GAD

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About This Item

經驗公式(希爾表示法):
C30H42O7
CAS號碼:
分子量::
514.65
MDL號碼:
分類程式碼代碼:
12352106
分類程式碼代碼:
12352200
NACRES:
NA.21

品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

-10 to -25°C

SMILES 字串

O[C@H]1C[C@@H]2[C@](CCC(=O)C2(C)C)(C3=C1[C@]4([C@@]([C@H](CC4=O)[C@@H](CC(=O)CC(C)C(=O)O)C)(CC3=O)C)C)C

InChI 密鑰

YTVGSCZIHGRVAV-IYAQLQCNSA-N

生化/生理作用

Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum that exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate, and pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition.
Major triterpenes isolated from Ganoderma lucidum that exhibit potent anticancer properties

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Zhendong Liu et al.
European journal of pharmacology, 824, 72-77 (2018-01-29)
Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated

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