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Key Documents

SML3402

Sigma-Aldrich

HSip-1 trifluoroacetate hydrate

≥98% (HPLC)

同義詞:

Cyclen-AF-Cu trifluoroacetate hydrate, HSip 1, HSip1, Hydrogen Sulfide imaging probe-1, [N-(3′,6′-Dihydroxy-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthen]-5-yl)-1,4,7,10-tetraazacyclododecane-1-acetamide-κN1,κN4,κN7,κN10]-copper(2+) trifluoroacetate hydrate

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About This Item

經驗公式(希爾表示法):
C30H33CuN5O6 · xC2HF3O2 · yH2O
分子量::
623.16 (anhydrous free base basis)
分類程式碼代碼:
41121706
分類程式碼代碼:
12352200
NACRES:
NA.21

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

green to black

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C1OC2(C3=CC=C(NC(C[N]45CC[N@@]6([H])CC[N]7([H])CC[N@]([Cu@+2]765)([H])CC4)=O)C=C13)C8=CC=C(C=C8OC9=CC(O)=CC=C92)O.[y H2O]

生化/生理作用

HSip-1 (Cyclen-AF-Cu; Hydrogen Sulfide imaging probe-1) is a sensitive hydrogen sulfide (H2S) fluorescent probe that displays a selective turn-on fluorescence response to sulfide anion (Ex/Em = 491/516 nm), but not GSH, L-Cys, DL-Hcy, 2-ME, DTT, SCN-, Na2SO3, Na2S2O3, or sodium ascorbate. HSip-1 is not membrane-permeable and is commonly employed for detecting H2S in media/buffers, cell lysates, blood, physiological fluids and tissue homogenates. HSip-1 is commonly used in the range from 1-100 μM depending on the H2S concentrations in samples, optimal probe concentration needs to be titred.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur
MedChemComm, 5(10), 1577-1583 (2014)
Development of a highly selective fluorescence probe for hydrogen sulfide
Journal of the American Chemical Society, 133(45), 18003-18005 (2011)

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