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Merck
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重要文件

SML3392

Sigma-Aldrich

BC-11 hydrobromide

≥98% (HPLC)

同義詞:

Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide

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About This Item

經驗公式(希爾表示法):
C8H11BN2O2S·HBr
CAS號碼:
分子量::
290.97
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 2 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

B(O)(O)c1ccc(cc1)CS\C(=N/[H])\N.Br

InChI

1S/C8H11BN2O2S.BrH/c10-8(11)14-5-6-1-3-7(4-2-6)9(12)13;/h1-4,12-13H,5H2,(H3,10,11);1H

InChI 密鑰

PAFZAMOVHIRQOD-UHFFFAOYSA-N

生化/生理作用

BC-11 is a potent and selective inhibitor of urokinase (urokinase-plasminogen activator, uPA). BC-11 inhibits clot lysis with no effect on clot formation. BC-11 exhibits anti-fibrotic activity and improves wound healing and scar quality after topical administration in mice.
potent and selective inhibitor of urokinase (urokinase-plasminogen activator, uPA)

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Alessandra Longo et al.
Molecules (Basel, Switzerland), 20(6), 9879-9889 (2015-06-02)
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at

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