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Merck
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Key Documents

SML3329

Sigma-Aldrich

Decursinol Angelate

≥98% (HPLC)

同義詞:

(2Z)​-2-​Methyl-2-​butenoic acid (7S)​-​7,​8-​dihydro-​8,​8-​dimethyl-​2-​oxo-​2H,​6H-​benzo[1,​2-​b:5,​4-​b′]​dipyran-​7-​yl ester, Acutilobin

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About This Item

經驗公式(希爾表示法):
C19H20O5
CAS號碼:
分子量::
328.36
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

-10 to -25°C

生化/生理作用

Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas that exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-κB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


分析證明 (COA)

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Sukkum Ngullie Chang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 132, 110699-110699 (2019-07-28)
Decursinol angelate (DA) is a pyranocoumarin purified from the roots of Angelica gigas. Here, we synthesized DA and determined its anti-inflammatory potential on TPA-induced mice ear inflammation. First, we evaluated the non-toxic behaviour of DA on HaCaT cells. Additionally, we
Bikash Thapa et al.
Biomolecules & therapeutics, 27(5), 466-473 (2019-03-29)
Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell responses
Salman Ul Islam et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-01)
Inflammation is considered the root cause of various inflammatory diseases, including cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of Angelica gigas, has been reported to exhibit potent anti-inflammatory effects. In this study, the anti-inflammatory effects of

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