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Merck
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Key Documents

SML3193

Sigma-Aldrich

(S)-GSK2920487A

≥98% (HPLC)

同義詞:

(S)-(4-fluorobenzo[b]thiophen-2-yl)(3-(5-methyl-1H-imidazol-1-yl)piperidin-1-yl)methanone, (S)-1, TCMDC-143498

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About This Item

經驗公式(希爾表示法):
C18H18FN3OS
分子量::
343.42
分類程式碼代碼:
12352200

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to gray

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(N1C[C@H](CCC1)N2C=CN=C2C)C3=CC4=C(S3)C=CC=C4F

生化/生理作用

(S)-GSK2920487A is a promising anti-leishmanial agent that potently and specifically inhibits oxidosqualene cyclase (OSC) of Leishmania donovani. (S)-GSK2920487A induces the accumulation of the 2,3-oxidosqualene, a substrate of OSC, in promastigotes and cell-free membrane preparations. It is active against axenic and intramacrophage amastigotes. Also, GSK2920487A is active against intracellular T. cruzi.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Tong Chen et al.
Journal of cellular biochemistry, 116(7), 1179-1189 (2015-03-06)
Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), provide a new cell source for regenerative medicine, disease modeling, drug discovery, and preclinical toxicity screening. Understanding of the onset and the
Luciana S Paradela et al.
Cell chemical biology, 28(5), 711-721 (2021-03-11)
Phenotypic screening identified a benzothiophene compound with activity against Leishmania donovani, the causative agent of visceral leishmaniasis. Using multiple orthogonal approaches, oxidosqualene cyclase (OSC), a key enzyme of sterol biosynthesis, was identified as the target of this racemic compound and

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