SML3010

Belinostat

≥98% (HPLC)

• 同義詞: (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide, (2E)-N-Hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide, (E)-N-Hydroxy-3-(3-(N-phenylsulfamoyl)phenyl)acrylamide, PX 105684, PX-105684, PX105684, PXD 101, PXD-101, PXD101
• 經驗公式（希爾表示法）: C₁₅H₁₄N₂O₄S
• CAS號碼: 866323-14-0
• 分子量：: 318.35
• MDL號碼: MFCD08064035
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: [S](=O)(=O)(Nc2ccccc2)c1cc(ccc1)\C=C\C(=O)NO
• InChI: 1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
• InChI 密鑰: NCNRHFGMJRPRSK-MDZDMXLPSA-N

描述

生化／生理作用

Belinostat (PX105684; PXD101) is a potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 41/125/30/216 nM, class IIA HDAC4/7/9 = 115/67/128 nM, class IIB HDAC6 = 82 nM) with anti-cancer efficacy in vitro and in vivo.

Potent, hydroxamate class pan-selective histone deacetylases (HDACs) inhibitor with anti-cancer efficacy in vitro and in vivo.

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H340,H361f,H373
• 防範說明: P201 - P202 - P260 - P280 - P308 + P313 - P405
• 危險分類: Muta. 1B - Repr. 2 - STOT RE 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable