推薦產品
生化／生理作用
Valiglurax is an orally available, CNS penetrant, potent and selective mGlu4 positive allosteric modulator (PAM).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
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Joseph D Panarese et al.
ACS medicinal chemistry letters, 10(3), 255-260 (2019-03-21)
Herein, we report the discovery of a novel potent, selective, CNS penetrant, and orally bioavailable mGlu4 PAM, VU0652957 (VU2957, Valiglurax). VU2957 possessed attractive in vitro and in vivo pharmacological and DMPK properties across species. To advance toward the clinic, a
Joseph D Panarese et al.
Bioorganic & medicinal chemistry letters, 29(2), 342-346 (2018-12-07)
This letter describes the first account of the chemical optimization (SAR and DMPK profiling) of a new series of mGlu4 positive allosteric modulators (PAMs), leading to the identification of VU0652957 (VU2957, Valiglurax), a compound profiled as a preclinical development candidate.
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