SML2812

AN1

≥98% (HPLC)

• 同義詞: 5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
• 經驗公式（希爾表示法）: C₁₅H₉Br₂NO₃
• CAS號碼: 486443-73-6
• 分子量：: 411.04
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
• InChI: 1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
• InChI 密鑰: GPKLWRHHVIBYEO-UHFFFAOYSA-N

描述

生化／生理作用

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.

brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable