SML2801

6-乙酰-7-脱乙酰福斯考灵

≥95% (HPLC)

• 同義詞: 6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮, 异佛司可林
• 經驗公式（希爾表示法）: C₂₂H₃₄O₇
• CAS號碼: 64657-21-2
• 分子量：: 410.50
• MDL號碼: MFCD00078929
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 光學活性: [α]/D -8 to -5°, c = 0.5 in chloroform-d
• 顏色: white to beige
• 溶解度: DMF:H₂O (9:1): 2 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
• InChI: 1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
• InChI 密鑰: CLOQVZCSBYBUPB-VDCUXWMXSA-N

描述

生化／生理作用

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H312
• 防範說明: P280 - P302 + P352 + P312 - P362 + P364 - P501
• 危險分類: Acute Tox. 4 Dermal
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3