SML2758
达格列净丙二醇一水合物
≥98% (HPLC)
同義詞:
(1S)-1,5-酐-1-C-[4-氯-3-[（4-乙氧基苯基）甲基]苯基]-D-葡萄糖醇（S）-丙烷-1,2-二醇（1:1）一水合物, BMS 512148 丙二醇水合物, BMS-512148 丙二醇水合物, 达格列净丙二醇水合物, 达格列净（S）-丙二醇一水合物, （2S,3R,4R,5S,6R）-2-（3-（4-乙氧基苄基）-4-氯苯基）-6-羟甲基-四氢-2H-吡喃-3,4,5-三醇丙二醇一水合物
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About This Item
經驗公式（希爾表示法）:
C21H25ClO6·C3H8O2·H2O
CAS號碼:
分子量：:
502.98
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D +17 to +25, c = 1.0 in chloroform-d
儲存條件
desiccated
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
−20°C
InChI
1S/C21H25ClO6.C3H8O2.H2O/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21;1-3(5)2-4;/h3-8,10,17-21,23-26H,2,9,11H2,1H3;3-5H,2H2,1H3;1H2/t17-,18-,19+,20-,21+;3-;/m10./s1
InChI 密鑰
GOADIQFWSVMMRJ-UPGAGZFNSA-N
尋找類似的產品？ 前往 產品比較指南
生化／生理作用
达格列净（BMS-512148）是一种口服活性、有效和选择性的肾钠依赖性葡萄糖共转运蛋白2（SGLT2；SLC5A2）抑制剂（人/大鼠SGLT2 IC50 = 1.1/3 nM，而人/大鼠SGLT1 IC50 = 1.39/0.6 μM；R-甲基-D-吡喃葡萄糖苷（AMG）摄取测定以及相应的CHO转染子）。达格列净通过防止肾脏葡萄糖重吸收过程并促进尿液中葡萄糖排泄，具有良好的药代动力学特性和口服利用度（口服1 mg/kg和6.6 mg/kg后，在大鼠和狗中分别降低了84%和83%），从而降低了血糖水平（在链脲佐菌素（STZ）诱导的高血糖大鼠中，在口服0.1 mg/kg后5小时降低了55%）体内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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