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Merck
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SML2696

Sigma-Aldrich

RSM932A

≥97% (HPLC)

同義詞:

1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI), 1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide, RSM 932A, TCD-717

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About This Item

經驗公式（希爾表示法）:
C46H38Cl2N4 · 2Br
CAS號碼:
850807-63-5
分子量：:
877.53
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥97% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

faint yellow to dark orange

溶解度

H2O: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CN(C1=CC=[N+](CC2=CC=C(C3=CC=C(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C6=CC=CC=C46)C=C3)C=C2)C7=CC=CC=C17)C8=CC=C(Cl)C=C8

InChI

1S/C46H38Cl2N4/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40/h3-30H,31-32H2,1-2H3/q+2

InChI 密鑰

QGYGTMZEJNOHNU-UHFFFAOYSA-N

生化／生理作用

RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines.
potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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Sean P Arlauckas et al.
Oncotarget, 8(10), 16518-16530 (2017-02-06)
Choline kinase alpha (ChoKα) overexpression is associated with an aggressive tumor phenotype. ChoKα inhibitors induce apoptosis in tumors, however validation of their specificity is difficult in vivo. We report the use of optical imaging to assess ChoKα status in cells
E Sanchez-Lopez et al.
Cell death & disease, 4, e933-e933 (2013-11-30)
Endoplasmic reticulum (ER) is a central organelle in eukaryotic cells that regulates protein synthesis and maturation. Perturbation of ER functions leads to ER stress, which has been previously associated with a broad variety of diseases. ER stress is generally regarded
Juan Carlos Lacal et al.
Molecular cancer therapeutics, 14(1), 31-39 (2014-12-10)
Choline kinase α (CHKA; here designated as ChoKα) is the first enzyme in the CDP-choline pathway, implicated in phospholipids metabolism. It is overexpressed in several human tumors such as breast, lung, bladder, colorectal, prostate, ovary, and liver. The overexpression of

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