SML2608

CSRM617 Hydrochloride

≥98% (HPLC)

• 同義詞: (2,3,4-Trihydroxyphenyl-methylidene)-hydrazino-2-amino-3-hydroxy-1-propanone hydrochloride, 2-Amino-3-hydroxy-N′-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride, 2-[(2,3,4-trihydroxyphenyl)methylene] serinehydrazide hydrochloride (1:1)
• 經驗公式（希爾表示法）: C₁₀H₁₃N₃O₅ · HCl
• CAS號碼: 1353749-74-2
• 分子量：: 291.69
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 2 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: OC1=C(C=CC(O)=C1O)C=NNC(C(CO)N)=O.Cl

描述

生化／生理作用

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 μM) and disrupts OC2 target genes promoter binding. CSRM617 blocks OC2-dependent prostate cancer growth in cultures (IC50 = 4-50 μM; 48 h) via apoptosis induction (fold of untreated annexin V population = 2.3/10 μM, 3.5/20 μM; 22Rv1) and exhibits in vivo efficacy against metastases as well as the growth of established 22Rv1 tumor in mice in vivo (50 mg/kg/day ip.).

安全資訊

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H317,H319,H341,H410
• 防範說明: P201 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable