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Merck
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Key Documents

SML2561

Sigma-Aldrich

ML162

≥98% (HPLC)

同義詞:

α-[(2-氯乙酰基)(3-氯-4-甲氧基苯基)氨基]-N-(2-苯乙基)-2-噻吩乙酰胺, 2-氯-N-(3-氯-4-甲氧基苯基)-N-(2-氧代-2-(苯乙基氨基)-1-(噻吩-2-基)乙基)乙酰胺, BRD-5421, BRD5421, CID 3689413, ML 162, ML-162, 分子库162

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About This Item

經驗公式(希爾表示法):
C23H22Cl2N2O3S
CAS號碼:
分子量::
477.40
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to very dark brown

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

生化/生理作用

ML162是一种小分子,可通过共价抑制细胞磷脂谷胱甘肽过氧化物酶(GPx-4;GPx4;GSHPx-4;PHGPx;SNGPx;snPHGPx)诱导铁死亡。癌症培养物中的合成致死性研究确定了诸如HRas(G12V)表达和富马酸水合酶(FH)缺失对ML162敏感性的影响因子(在BJeLR-HRas(G12V)&UOK262-FH-/-培养物中IC50分别为25 nM & 35 nM)。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Michel Weïwer et al.
Bioorganic & medicinal chemistry letters, 22(4), 1822-1826 (2012-02-03)
Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from
Emilie Logie et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Disease relapse and therapy resistance remain key challenges in treating multiple myeloma. Underlying (epi-)mutational events can promote myelomagenesis and contribute to multi-drug and apoptosis resistance. Therefore, compounds inducing ferroptosis, a form of iron and lipid peroxidation-regulated cell death, are appealing
Amrita Basu et al.
Cell, 154(5), 1151-1161 (2013-09-03)
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) profiling to identify additional biomarkers of small-molecule sensitivities. We have quantitatively measured the sensitivity
Vasanthi S Viswanathan et al.
Nature, 547(7664), 453-457 (2017-07-06)
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated with resistance to multiple
Kenichi Shimada et al.
Cell chemical biology, 23(2), 225-235 (2016-02-09)
Precision medicine in oncology requires not only identification of cancer-associated mutations but also effective drugs for each cancer genotype, which is still a largely unsolved problem. One approach for the latter challenge has been large-scale testing of small molecules in

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