SML2410

ABC99

≥98% (HPLC)

• 同義詞: 7-(4-Chlorobenzyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 2,3-dihydro-4Hbenzo[b][1,4]oxazine-4-carboxylate
• 經驗公式（希爾表示法）: C₂₂H₂₁ClN₄O₅
• CAS號碼: 2331255-53-7
• 分子量：: 456.88
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: O=C(ON(C(N1C2CN(CC1)CC3=CC=C(C=C3)Cl)=O)C2=O)N4C5=CC=CC=C5OCC4

描述

生化／生理作用

ABC99 is an N-hydroxyhydantoin (NHH) carbamate-based irreversible, potent and selective inhibitor against the serine hydrolase activity of the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM against NOTUM-mediated labeling of fluorophosphonate (FP) probe), an enzyme that reverses the posttranslational O-linked palmitoleate modification of Wnt proteins. ABC99 prevents NOTUM-mediated negative regulation against Wnt3A-dependent cellular signaling (EC50 = 89 nM by HEK293T TOPflash reporter assay) with excellent selectivity over 65 other serine hydrolases, including PPT1.

Inhibition of NOTUM has therapeutic use in treating degenerative diseases including osteopenia and osteoporosis.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable