SML2213
CPI-637
≥98% (HPLC)
同義詞:
(4R)-1,3,4,5-Tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-2H-1,5-benzodiazepin-2-one, (4R)-4-Methyl-6-[1-methyl-3-(1-methylpyrazol-4-yl)indazol-5-yl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one, 2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-, CPI 637
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About This Item
推薦產品
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -39 to -49°, c = 1.0 in chloroform-d
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
−20°C
生化／生理作用
CPI-637 is a cell penetrant, selective and potent CBP/p300 bromodomain inhibitor.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Terry D Crawford et al.
Journal of medicinal chemistry, 59(23), 10549-10563 (2016-09-30)
The single bromodomain of the closely related transcriptional regulators CBP/EP300 is a target of much recent interest in cancer and immune system regulation. A co-crystal structure of a ligand-efficient screening hit and the CBP bromodomain guided initial design targeting the
Alexander M Taylor et al.
ACS medicinal chemistry letters, 7(5), 531-536 (2016-05-18)
CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of our effort to explore the potential therapeutic implications of selectively targeting bromodomains, we set out to identify a CBP/EP300 bromodomain
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