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SML2094

Sigma-Aldrich

BIBO 3304 trifluoroacetate salt

≥98% (HPLC)

同義詞:

BIBO3304, N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-a-phenyl-benzeneacetamide trifluoroacetate

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About This Item

經驗公式（希爾表示法）:
C29H35N7O3 · xC2HF3O2
CAS號碼:
191868-13-0
分子量：:
529.63 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C29H35N7O3/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39)/t24-/m1/s1

InChI 密鑰

TVMJSGGZULFVCZ-XMMPIXPASA-N

生化／生理作用

BIBO 3304 is a highly potent and selective NPY Y1 receptor antagonist that inhibits food intake induces by NPY (neuropeptide Y) or fasting in rodents. BIBO3304 eliminates NPY effects on fear extinction retrieval in rats.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

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H A Wieland et al.
British journal of pharmacology, 125(3), 549-555 (1998-11-07)
1. The novel Y1-selective argininamide derivative BIBO 3304 ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) has been synthesized and was examined for its subtype selectivity, its in vitro antagonistic properties and its food intake inhibitory properties. 2. BIBO 3304 displayed subnanomolar affinity for both
Lauren L Vollmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(4), 1306-1315 (2016-01-29)
Neuropeptide Y (NPY), a 36 aa peptide, regulates stress and emotional behaviors. Preclinical and clinical studies support an association of NPY with trauma-evoked syndromes such as posttraumatic stress disorder (PTSD), although the exact contribution of NPY is not clear. In
Shlomi Cohen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 774-790 (2014-09-23)
The hypothalamic-pituitary-adrenal (HPA) axis displays a characteristic circadian pattern of corticosterone release, with higher levels at the onset of the active phase and lower levels at the onset of the inactive phase. As corticosterone levels modify the response to stress

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