推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
FC(F)(F)c1cc(c(cc1)Cl)NC(=O)CN2CCN(CC2)C(=O)c3[o]ccc3
InChI
1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)
InChI 密鑰
OXKNHBBDOIMFFQ-UHFFFAOYSA-N
尋找類似的產品？ 前往 產品比較指南
生化／生理作用
ML348 是一种底物竞争性、可逆和 APT1 选择性酰基蛋白硫酯酶（APT）抑制剂（对 APT1 的 IC50/Ki = 840 nM/300 nM；对 APT2 的 IC50 & Ki >10 μM）。 ML348 可有效抑制培养物中（在 HEK293T & 小鼠 T 细胞中为 >95％；5 μM 持续 4 h）和小鼠体内（腹腔注射 50 mg/kg 后 4 小时，肺/心脏/肾脏中为 >90％，脑组织中约为 50％）的细胞 APT1 活性，而不会影响超过 15 种细胞丝氨酸水解酶和 APT2。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Alexander Adibekian et al.
Journal of the American Chemical Society, 134(25), 10345-10348 (2012-06-14)
The development of small-molecule inhibitors for perturbing enzyme function requires assays to confirm that the inhibitors interact with their enzymatic targets in vivo. Determining target engagement in vivo can be particularly challenging for poorly characterized enzymes that lack known biomarkers
Rahul S Kathayat et al.
Nature chemical biology, 13(2), 150-152 (2016-12-20)
Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation), but the regulation of depalmitoylation is poorly understood. Here, we develop 'depalmitoylation probes' (DPPs), small-molecule fluorophores, to monitor the endogenous activity levels of 'erasers' of S-palmitoylation, acylprotein
Jeannie L Hernandez et al.
Cell chemical biology, 24(1), 87-97 (2017-01-10)
The multidomain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell-cell junctions to the cytosol, correlating with enhanced growth signaling and malignancy.
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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