SML1671

NCT-503 Inactive Control

≥98% (HPLC)

• 同義詞: N-(4,6-Dimethylpyridin-2-yl)-4-(pyridin-4-yl)piperazine-1-carbothioamide
• 經驗公式（希爾表示法）: C₁₇H₂₁N₅S
• CAS號碼: 1914971-16-6
• 分子量：: 327.45
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826006
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 5 mg/mL, clear (warmed)
• 儲存溫度: 2-8°C
• SMILES 字串: CC1=CC(NC(N2CCN(C3=CC=NC=C3)CC2)=S)=NC(C)=C1
• InChI: 1S/C17H21N5S/c1-13-11-14(2)19-16(12-13)20-17(23)22-9-7-21(8-10-22)15-3-5-18-6-4-15/h3-6,11-12H,7-10H2,1-2H3,(H,19,20,23)
• InChI 密鑰: ITLPIAAGIQAGRA-UHFFFAOYSA-N

描述

應用

NCT-503 Inactive Control has been used as a small molecule inhibitor of phosphoglycerate dehydrogenase in neuroblastoma cells.

生化／生理作用

NCT-503 Inactive Control is the inactive control probe for NCT-503, which is an inhibitor of phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first, rate-limiting step of glucose-derived serine synthesis. NCT-503 Inactive Control has an IC₅₀ value >57 μM for PHGDH. NCT-503 has an IC₅₀ value of 2.5 μM for PHGDH. NCT-503 Inactive Control is water soluble and has good stability, similar to NCT-503.

推薦產品

The active PHGDH inhibitor, NCT-503, is available from Sigma. To learn more about and purchase NCT-503, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315
• 防範說明: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• 危險分類: Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable