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Key Documents

SML1621

Sigma-Aldrich

OSMI-1

≥98% (HPLC), powder, OGT inhibitor

同義詞:

(αR)-α-[[(1,2-二氢-2-氧代-6-喹啉基)磺酰基]氨基]-N-(2-呋喃基甲基)-2-甲氧基-N-(2-噻吩甲基)苯乙酰胺, OSMI 1

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About This Item

經驗公式(希爾表示法):
C28H25N3O6S2
CAS號碼:
分子量::
563.64
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

product name

OSMI-1, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 20 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

O=C(N1)C=CC2=C1C=CC(S(N[C@H](C3=C(OC)C=CC=C3)C(N(CC4=CC=CS4)CC5=CC=CO5)=O)(=O)=O)=C2

InChI

1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1

InChI 密鑰

IYIGLWQQAMROOF-HHHXNRCGSA-N

應用

OSMI-1(OGT的小分子抑制剂)已可用于邻位连接分析、Sox2(SRY(性别决定区Y)-Box 2)双荧光素酶报告基因检测、Sox2 ELISA(酶联免疫吸附测定)以及其他 体内 方法 ,以研究 O-连接的β-N-乙酰氨基葡萄糖(O-GlcNAc)介导的癌症自我更新基因的调控。它还被用于研究由O-GlcNAc转移酶介导的Hippo途径调节。

生化/生理作用

OSMI-1是一种细胞渗透性OGT(O-GlcNAc转移酶)抑制剂。
在翻译后修饰过程中,OGT可催化 N-乙酰葡糖胺部分与多种蛋白质的连接。抑制OGT活性,可能会降低病毒在感染过程中的复制率,如单纯疱疹病毒性疾病。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Regulation of the hippo-YAP pathway by glucose sensor O-GlcNAcylation.
Peng C, et al.
Molecular Cell, 68(3), 591-604 (2018)
O-GlcNAc modification of oncogenic transcription factor Sox2 promotes protein stability and regulates self-renewal in pancreatic cancer.
Sharma N, et al.
bioRxiv, 345223-345223 (2018)
O-GlcNAc transferase inhibitors: current tools and future challenges.
Trapannone R, et al.
Biochemical Society Transactions, 44(1), 88-93 (2016)
Nikita S Sharma et al.
Theranostics, 9(12), 3410-3424 (2019-07-10)
Pancreatic adenocarcinoma (PDAC) claims more than 90% of the patients diagnosed with the disease owing to its aggressive biology that is manifested by high rate of tumor recurrence. Aberrant upregulation in the transcriptional activity of proteins involved in self-renewal like
Hye-Yeon Kim et al.
Bioprocess and biosystems engineering, 43(5), 863-875 (2020-01-26)
O-Glycosylation occurs in recombinant proteins produced by CHO cells, but this phenomenon has not been studied extensively. Here, we report that rituximab is an O-linked N-acetyl-glucosaminylated (O-GlcNAcylated) protein and the production of rituximab is increased by thiamet G, an inhibitor

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