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重要文件

SML1612

Sigma-Aldrich

2-PMPA

≥98% (HPLC), powder, glutamate carboxypeptidase II inhibitor

同義詞:

2-(膦酰基甲基)-戊二酸, 2-膦酰基甲基戊二酸, PMPA

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About This Item

經驗公式(希爾表示法):
C6H11O7P
CAS號碼:
分子量::
226.12
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

產品名稱

2-PMPA, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 20 mg/mL, clear

儲存溫度

room temp

SMILES 字串

O=C(O)CCC(C(O)=O)CP(O)(O)=O

InChI

1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13)

InChI 密鑰

ISEYJGQFXSTPMQ-UHFFFAOYSA-N

相關類別

生化/生理作用

2-PMPA 是一种有效的(IC50 ~ 1 nM)选择性谷氨酸羧肽酶 II(GCPII)抑制剂,也称为 N-乙酰基-L-天冬氨酰-L-谷氨酸肽酶 I(NAALADase I)、NAAG 肽酶或前列腺素-特异性膜抗原(PSMA)。2-PMPA 具有神经保护活性。2-PMPA 在多发性硬化症的 EAE 模型中已被证明可预防和治疗认知障碍,并防止梭曼诱导的神经病理学。
2-PMPA 是谷氨酸羧肽酶 II(GCPII)的有效选择性抑制剂。
2-(膦酰基甲基)戊二酸(2-PMPA)阻断由低单位剂量的可卡因维持的静脉内可卡因自我给药。此外,它还抑制可卡因诱导的寻求毒品行为的恢复。2-PMPA 可降低麻醉小鼠脑内血氧水平依赖(BOLD)信号。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice
Baslow M H, et al.
Journal of Molecular Neuroscience, 26(1), 1-16 (2005)
Mena Asha Krishnan et al.
Biomaterials science, 9(6), 2295-2312 (2021-02-09)
The current challenge in fluorescence guided surgery (FGS) for prostate cancer (PCa) is in the design of imaging probes with high selectivity, clear visualization of tumour margins, and minimal toxicity. This report aims to design and develop a novel NIR-nanoprobe
Inhibition of N-acetylated-alpha-Linked-Acidic Dipeptidase (NAALADase) by 2-PMPA Attenuates Cocaine-Induced Relapse in Rats: A NAAG-mGluR2/3-Mediated Mechanism
Xi Z X, et al.
Journal of Neurochemistry, 112(2), 564-564 (2010)
Eden Kapcan et al.
Current protocols in chemical biology, 12(4), e88-e88 (2020-12-17)
The emergence of covalent inhibitors and chemoproteomic probes in translational chemical biology research requires the development of robust biophysical and analytical methods to characterize their complex interactions with target biomolecules. Importantly, these methods must efficiently assess target selectivity and accurately
Mena Asha Krishnan et al.
Current protocols in chemical biology, 10(4), e50-e50 (2018-09-14)
Present treatment strategies focus on minimizing unwanted toxicity to healthy cells during chemotherapeutic treatment. This is achieved by developing strategies to selectively deliver drugs to malignant cells over-expressing specific protein biomarkers. The drugs are attached via a self-immolative linker to

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