SML1571

S14161

≥98% (HPLC)

• 同義詞: 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran, 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene, Pichromene
• 經驗公式（希爾表示法）: C₁₇H₁₄FNO₄
• CAS號碼: 883046-50-2
• 分子量：: 315.30
• MDL號碼: MFCD00112055
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825969
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated; protect from light
• 顏色: white to beige
• 儲存溫度: −20°C
• SMILES 字串: FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2
• InChI: 1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3
• InChI 密鑰: BFZXDHIUPNWOMT-UHFFFAOYSA-N

描述

生化／生理作用

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315
• 防範說明: P264 - P280 - P302 + P352 - P332 + P313 - P362 + P364
• 危險分類: Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3