SML1310

NSC756093

≥98% (HPLC)

• 同義詞: 4,9-Dihydro-4-(2-hydroxyethyl)-6-methoxy-9-phenyl-furo[3,4-b]quinolin-1(3H)-one, 4-(2-Hydroxyethyl)-6-methoxy-9-phenyl-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one
• 經驗公式（希爾表示法）: C₂₀H₁₉NO₄
• CAS號碼: 1629908-92-4
• 分子量：: 337.37
• MDL號碼: MFCD28902215
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825776
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: OCCN1C2=C(C(OC2)=O)C(C3=CC=CC=C3)C4=C1C=C(OC)C=C4
• InChI: 1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3
• InChI 密鑰: SMEJQLRLHKWIFV-UHFFFAOYSA-N

描述

生化／生理作用

NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction that inhibits proliferation of paclitaxel resistant cancer cells. Apparently, NSC756093 stabilizes a conformation of GBP1 not suitable for binding to PIM1.

NSC756093, a podophyllotoxin analog, is a potent and specific inhibitor of GBP1:PIM1 interaction.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302,H400
• 防範說明: P264 - P270 - P273 - P301 + P312 - P391 - P501
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable