SML1148

YIL-781 hydrochloride

≥98% (HPLC)

• 同義詞: 6-(4-Fluorophenoxy)-2-methyl-3-[[(3S)-1-(1-methylethyl)-3-piperidinyl]methyl]-4(3H)-quinazolinone hydrochloride
• 經驗公式（希爾表示法）: C₂₄H₂₈FN₃O₂ · xHCl
• CAS號碼: 875258-85-8
• 分子量：: 409.50 (free base basis)
• MDL號碼: MFCD19690924
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329825682
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: , white to yellow to light brown
• 溶解度: H₂O: 2 mg/mL, clear (warmed)
• 儲存溫度: room temp
• SMILES 字串: CC(C)N(CCC1)C[C@H]1CN(C(C)=N2)C(C3=C2C=CC(OC4=CC=C(F)C=C4)=C3)=O.Cl
• InChI: 1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
• InChI 密鑰: QQGRMONBDBMLSP-FERBBOLQSA-N

描述

應用

YIL-781 has been used as a ghrelin receptor (GHSR) antagonist in combination with methanandamide (mAEA) to study its effect on gastric vagal afferent mechanosensitivity.

生化／生理作用

YIL-781 is a Ghrelin receptor antagonist.

YIL-781 is a potent antagonist (Ki = 17 nM) of the growth hormone secretagogue receptor (GHS-R1). YIL-781 blocks ghrelin-induced reduction of insulin secretion in rat islets. In vivo, the compound YIL-781 improves glucose tolerance and reduces weight gain.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable