SML1013

PRT4165

≥98% (HPLC)

• 同義詞: 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione; 2-(3-Pyridylmethylene)-1,3-indandione, NSC 600157
• 經驗公式（希爾表示法）: C₁₅H₉NO₂
• CAS號碼: 31083-55-3
• 分子量：: 235.24
• MDL號碼: MFCD00435709
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825631
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 20 mg/mL, clear
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1C(C(C2=C1C=CC=C2)=O)=CC3=CN=CC=C3
• InChI: 1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
• InChI 密鑰: OMHZFEWYVFWVLI-UHFFFAOYSA-N

描述

生化／生理作用

PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX.

特點和優勢

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安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable