SML0924

ML167

≥98% (HPLC)

• 同義詞: 5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol, CID 44968231, NCGC00188654
• 經驗公式（希爾表示法）: C₁₉H₁₇N₃O₃
• CAS號碼: 1285702-20-6
• 分子量：: 335.36
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: off-white to gray-brown
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: −20°C
• InChI: 1S/C19H17N3O3/c1-12-2-4-14(24-12)9-20-19-16-8-13(3-6-17(16)21-11-22-19)18-7-5-15(10-23)25-18/h2-8,11,23H,9-10H2,1H3,(H,20,21,22)
• InChI 密鑰: ROCFOIBAEVAOLQ-UHFFFAOYSA-N

描述

生化／生理作用

ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC₅₀ of 136 nM for Clk4, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B, and minimal activity against a panel of other kinases tested. The Cdc2-like kinases (Clk′s) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk′s) are involved in regulation of gene splicing. The Cdc2-like kinases phosphorylate the serine/arginine-rich (SR) proteins, a major component of the spliceosome.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable