SML0664

LM11A-31 dihydrochloride

≥95% (HPLC)

• 同義詞: 2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
• 經驗公式（希爾表示法）: C₁₂H₂₅N₃O₂ · 2HCl
• CAS號碼: 1214672-15-7
• 分子量：: 316.27
• MDL號碼: MFCD11505486
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329825578
• NACRES: NA.77

屬性

• 化驗: ≥95% (HPLC)
• 形狀: oil
• 儲存條件: desiccated
• 顏色: colorless to yellow
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
• InChI: 1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
• InChI 密鑰: LLIHJRRZJDEKLB-UHFFFAOYSA-N

描述

應用

LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.

生化／生理作用

LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.

LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.

安全資訊

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H315,H319,H335,H410
• 防範說明: P273 - P302 + P352 - P305 + P351 + P338
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable