SML0448

URB937

≥95% (HPLC)

• 同義詞: Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester
• 經驗公式（希爾表示法）: C₂₀H₂₂N₂O₄
• CAS號碼: 1357160-72-5
• 分子量：: 354.40
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder (1:1 ratio of product to ethanol)
• 顏色: white to beige
• 溶解度: DMSO: 15 mg/mL, clear
• 儲存溫度: −20°C
• InChI: 1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
• InChI 密鑰: CMEQHOXCIGFZNJ-UHFFFAOYSA-N

描述

生化／生理作用

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED₅₀ for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable