SML0391

SB-268262

≥98% (HPLC)

• 同義詞: (+/-)-SB-273779, N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
• 經驗公式（希爾表示法）: C₁₈H₁₅N₃O₄S₂
• CAS號碼: 217438-17-0
• 分子量：: 401.46
• MDL號碼: MFCD10565932
• 分類程式碼代碼: 41106305
• PubChem物質ID: 329825388
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: >5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: CN(C(=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)c2nccs2)c3ccccc3C
• InChI: 1S/C18H15N3O4S2/c1-12-5-3-4-6-14(12)20(2)17(22)13-7-8-16(15(11-13)21(23)24)27(25)18-19-9-10-26-18/h3-11H,1-2H3
• InChI 密鑰: YXHLPJQQPOMPGE-UHFFFAOYSA-N

描述

生化／生理作用

SB-268262 is a selective non-peptide antagonist at the CGRP1 receptor.

SB-268262 is a selective non-peptide antagonist at the CGRP1 receptor. SB-268262 inhibits CGRP binding, and CGRP-mediated stimulation of adenylyl cyclase activity in human neuroblastoma cells with IC⁵⁰ values of 240 and 830 nM, respectively.

特點和優勢

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H319
• 防範說明: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable